Type 4 Cyclic Nucleotide Phosphodiesterases

A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.

Also Known As:

Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterase PDE4 Family; Cyclic Nucleotide Phosphodiesterases, Type 4A; Cyclic Nucleotide Phosphodiesterases, Type 4A5; Cyclic Nucleotide Phosphodiesterases, Type 4B; Cyclic Nucleotide Phosphodiesterases, Type 4C; Cyclic Nucleotide Phosphodiesterases, Type 4D; Cyclic Nucleotide Phosphodiesterases, Type 4D3; PDE4 Phosphodiesterases; PDE4D3 Phosphodiesterase; Phosphodiesterase 4; Phosphodiesterase 4A; Phosphodiesterase 4B; Phosphodiesterase 4C; Phosphodiesterase 4D; Phosphodiesterase IV; Phosphodiesterase-4; Type 4 Cyclic Nucleotide Phosphodiesterase; cAMP-Specific Phosphodiesterase 4A5; Phosphodiesterase 4A5, cAMP-Specific; Phosphodiesterase, PDE4D3; Phosphodiesterases, PDE4; cAMP Specific Phosphodiesterase 4A5

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Diester Hydrolases: 2391
        3',5'-Cyclic-AMP Phosphodiesterases: 185
        Type 4 Cyclic Nucleotide Phosphodiesterases: 824
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - 3',5'-Cyclic-AMP Phosphodiesterases: 185
      - Type 4 Cyclic Nucleotide Phosphodiesterases: 824

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Disease

Drug/Important Bio-Agent (IBA)